Senior Director, Clinical Scientist

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

MAIN PURPOSE OF JOB

Build & Inspire a High-Performing Team: Attract, mentor, and scale a world-class early clinical scientist organization across diverse therapeutic areas. Foster a culture of scientific rigor, innovation, and career development.

Define Enterprise Standards for Clinical Scientists: Establish and champion global standards, best practices, and frameworks for clinical scientists across all development phases, primarily focused on early phase, and all therapeutic areas. Elevate operational quality and ensure scientific consistency across clinical development.

Drive Cross-Portfolio Strategic Data Reviews and Support Publication Plans: For the early-stage clinical portfolio, partner closely with Clinical Program Leads (while mentoring the study level clinical scientist), to synthesize and interrogate emerging data in order to translate complex clinical findings into both robust publication plans and actionable development strategies that de-risk programs and accelerate key milestones.

KEY RESPONSIBILITIES

People Leadership & Capability Building: Recruit, mentor, and line manage clinical scientists across therapeutic areas while defining functional competencies and career pathways. Foster an environment of scientific excellence and accountability to support scientists embedded within study teams.

Strategic Workforce Planning: Partner with Business Planning and Operations to forecast functional capacity and dynamically allocate clinical scientist resources. Ensure appropriate talent deployment to match current pipeline milestones and future portfolio growth.

Quality & Document Governance: Oversee study-level clinical scientists in authoring high-quality clinical and regulatory documents (e.g., protocols, IBs, CSRs), ensuring rigorous GCP compliance and tight alignment with trial objectives.

Compliance & Operational Frameworks: Establish and periodically revise company-wide clinical science standards, SOPs, and best practices in close partnership with Clinical Operations, Biometrics, Regulatory Affairs and Compliance. Cultivate an ongoing culture of inspection-readiness and adherence to global ICH-GCP regulations across all programs.

Data Synthesis & Pipeline Strategy: Direct program- and platform-level clinical data reviews in close partnership with Clinical Program Leads. Interrogate emerging safety, biomarker, and efficacy readouts to de-risk assets and drive evidence-based development decisions.

Publication & External Dissemination: In close collaboration with Clinical Program Leads and Clinical Study Leads, shape and steer comprehensive scientific publication strategies for early-phase clinical assets. When needed, lead or oversee the authoring of scientific congress abstracts/presentations as well as primary peer-reviewed manuscripts and represent Clinical Sciences in strategic investigator engagements.

OTHER DUTIES

Provide expert, collegial support and leadership to all members of the drug development team to ensure full success of the company’s portfolio objectives and regulatory milestones.
Identify opportunities for continuous improvement and lead process improvement initiatives. Establish best practices and ensure a consistent approach is used across studies and teams.
Foster cross-functional collaboration and develop potential solutions to study issues that may impact budget, resources, and/or timelines.

SUPERVISORY RESPONSIBILITY

This role has supervisory duties associated as noted below:

Oversee direct report(s) to ensure quality and compliance of their work. Provide direction, mentoring, and support.
Accountable for ensuring all study deliverables and milestones in the assigned Program are met with quality and within timelines.
Provide direction and support to direct report(s) to ensure consistent approach and process to study execution and procedures amongst various program assets.
Serve as a point of escalation for more junior clinical scientists.
Escalate issues to senior leadership as appropriate.

Essential Experience & knowledge

Oncology Drug Development Strategy: Extensive clinical development experience in oncology, demonstrating deep expertise in designing and advancing early-phase programs through to proof-of-concept and late-stage translation. Proven track record of navigating complex clinical development pathways while maintaining unwavering commitment to patient safety governance.

People Leadership & Resourcing: Proven track record of recruiting, mentoring, and line managing clinical scientists across diverse therapeutic backgrounds and dispersed global geographies. Demonstrated capability in functional capacity modeling and strategic workforce planning to effectively balance resource allocation against pipeline demands.

Data Synthesis & Scientific Dissemination: Exceptional capability in interrogating, analyzing, and synthesizing complex clinical, biomarker, and translational data to guide strategic decision-making. Demonstrated track record of delivering high-impact peer-reviewed publications, congress presentations, and leading the authoring of core clinical documents (e.g., protocols, IBs, CSRs).

Regulatory Compliance & Clinical Governance: Deep expertise in global ICH-GCP principles, clinical development framework, and regulatory requirements, with demonstrated ability to embed inspection-ready practices study teams. Proven experience establishing and continuously improving departmental standards (e.g., SOPs, guidance documents, and work instructions) through cross-functional leadership.

Cross-Functional Leadership & Strategic Influence: Exceptional interpersonal, collaboration, and stakeholder management skills, with proven ability to align cross-functional teams and influence senior executive leadership. Agility in creative problem-solving and driving milestone delivery within fast-paced, matrixed environments.

Desirable

Background in immunology.
Experience with immune therapies.
Experience supporting interactions with global health authorities in support of IND / first-in-human studies and/or BLA/labelling. Experience incorporating, implementing, and evaluating translational endpoints as well as integrating complex clinical and translational data (eg, for dose selection and justification)

Education & qualifications

PhD, Pharm D, MS or BS in a related scientific subject.
Experience in oncology drug development.
10+ years of pharmaceutical industry experience with at least 5 years of clinical development experience.

Other

Periodic travel (~15-20%) to participating study sites as well as between Immunocore US sites will be required (includes overnight and international travel).
Attendance of leading industry meetings as required.